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Improved active solubility
Helps dissolve compatible actives and distribute them through a formulation.
High-Purity Formulation Solvent
AC-DMI
INCI name: Dimethyl Isosorbide
CAS No. 5306-85-4
SOLVENT SUPPORT FOR HARD-TO-DISSOLVE ACTIVES
High Solubilizing CapacityEnhanced PenetrationLightweight Feel
AC-DMI is a liquid solvent that enhances the solubility of poorly soluble active ingredients. It dissolves a wide range of components, increases skin penetration, boosts the efficacy of active ingredients, and provides a non-greasy, elegant skin feel. It is ideally suited for high-performance serums, toners, and personal care formulations.
Specifications
AC-DMI specifications
| INCI Name | Dimethyl Isosorbide |
|---|---|
| CAS No. | 5306-85-4 |
| Appearance | Clear, colorless liquid |
| Assay | ≥99.0% |
| Specific gravity | 1.15–1.17 |
Formulation profile
Solvent-system compatibility
| Water and polyols | For mixed aqueous solvent systems. |
|---|---|
| Organic formulation media | Compatible with many organic solvents and nonionic surfactants. |
| Active concentrates | A liquid medium for preparing an active premix before incorporation. |
Function and performance
Dissolution and formulation flexibility
AC-DMI helps formulators work with actives that are difficult to incorporate.
Flexible solvent blending
Can be combined with other formulation solvents to adjust the vehicle around the selected active.
Application
AC-DMI formulation guide
- Prepare the active premixDetermine solubility in AC-DMI and the intended solvent blend.
- Control processing conditionsInitial formulation window: pH 3–7 and temperature no higher than 80°C. Avoid strong oxidants such as hydrogen peroxide.
- Test after dilutionCheck clarity and precipitation after the premix enters the finished formula, including during storage.
Applications
SerumsEmulsionsHair careSelf-tanning products
Documents and samples
AC-DMI technical support
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FAQ
AC-DMI questions
What is AC-DMI used for in cosmetic formulations?
AC-DMI (Dimethyl Isosorbide) is a liquid solvent used to improve the solubility of poorly soluble active ingredients. It can be used in active premixes, serums, toners and emulsions.
Is AC-DMI compatible with water and other solvents?
AC-DMI is miscible with water and most organic solvents. It can be used with polyols such as glycerin and with ethanol. Compatibility with the complete formulation should be checked at the intended concentrations.
How much AC-DMI should be added to a formula?
The amount of AC-DMI depends on the active ingredient, its target concentration and the other solvents in the formula. Choose a level that dissolves the active, then check that it remains dissolved after incorporation and during storage.
How should AC-DMI be incorporated into a formula?
AC-DMI can be used to prepare an active premix before incorporation into the formula. Check solubility in AC-DMI or the intended solvent blend, then mix the premix into the formulation and check for precipitation after dilution.
What pH and processing temperature are suitable for AC-DMI?
For formulation development, use pH 3–7 and a processing temperature no higher than 80°C as starting conditions. The active ingredient and the complete formulation may require a narrower processing range.
Which ingredients should be avoided when using AC-DMI?
Avoid combining AC-DMI with strong oxidizing agents, such as hydrogen peroxide.
How does AC-DMI support active delivery?
AC-DMI helps dissolve active ingredients and can influence their distribution between the formulation and skin. The effect depends on the active and the complete solvent system; greater solubility does not necessarily mean greater skin delivery.
