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Enzyme-Based Production
An enzyme-based biotechnology process supports consistent production of high-purity Alpha-Arbutin.
Enzyme-Produced Brightening Active
AC-α-Arbutin
INCI name: Alpha-Arbutin
CAS No. 84380-01-8
HIGH-PURITY, WATER-SOLUBLE BRIGHTENING SUPPORT
≥99% Assay
Enzyme-Based Production
pH 5-7 Formula Window
Process Below 40°C
Hydroquinone ≤10 ppm
AC-α-Arbutin is ANECO Alpha-Arbutin produced through an enzyme-based biotechnology process for brightening serums, creams, lotions and BB/CC formulas. It contains at least 99% Alpha-Arbutin by HPLC, is highly soluble in cold water, inhibits tyrosinase and controls hydroquinone to no more than 10 ppm.
≥99%
Assay specification for AC-α-Arbutin.
Biocatalysis
Enzymatic synthesis enables a highly selective and efficient production process.
≤10 ppm
Hydroquinone specification limit.
Product Identity
AC-α-Arbutin Specification Snapshot
Review identity, assay, hydroquinone control and microbial limits before formulation or procurement qualification.
| Product Name | AC-α-Arbutin | INCI Name | Alpha-Arbutin |
|---|---|---|---|
| CAS No. | 84380-01-8 | EC / EINECS No. | 440-470-8 |
| Molecular Formula | C12H16O7 | Molecular Weight | 272 g/mol |
| Appearance | White crystalline powder | Assay | ≥99.0% |
| Clarity of Water Solution | Transparent, colorless, with no suspended matter | pH | 5.0-7.0 |
| Loss on Drying | ≤1.0% | Residue on Ignition | ≤0.5% |
| Hydroquinone | ≤10 ppm | Heavy Metals | ≤10 ppm |
| Total plate count | ≤1,000 cfu/g | Yeast & Molds | ≤100 cfu/g |
Defined Impurity Control
Hydroquinone and heavy metals are each controlled to no more than 10 ppm.
Cold-Water Incorporation
Solubility reaches 151 g/L at 20°C, supporting water-phase incorporation with temperature and oxidation control.
Use-Level and Process Windows
AC-α-Arbutin Formulation Guidance
Recommended use levels vary by product area and formula format; confirm final limits for the target market.
| Face and Neck Products | Up to 2.0%. |
|---|---|
| Body Products | Up to 0.5%. |
| Exfoliant / Penetration-Enhancer Systems | Up to 0.2%. |
| BB / CC Creams | 0.5-2.0%. |
| Recommended Formula pH | 5-7 for stability screening. |
| Processing Temperature | Below 40°C is preferred. |
Performance
Tyrosinase Inhibition and Brightening Performance
IC50 of 1.0 mmol/L in a human-cell-lysate tyrosinase test, plus a one-month 1% Alpha-Arbutin emulsion study with 80 participants.
Alpha-Arbutin IC50
IC50: 1.0 mmol/L in a human-cell-lysate tyrosinase test.
Beta-Arbutin Comparator
IC50: 9.0 mmol/L in the same tyrosinase test.
80 Participants
One-month clinical study demonstrated superior brightening efficacy of 1% α-Arbutin compared with β-Arbutin.
2% Alpha-Arbutin
Three-month clinical study showed significant improvement in liver spots.
Tyrosinase Inhibition
Helps reduce excess melanin formation by inhibiting tyrosinase activity.
High Water Solubility
151 g/L water solubility at 20°C for serums, essences, lotions and creams.
Formula Compatibility
Compatible with UV filters and ethanol, subject to stability testing.
Niacinamide Pairing
Pairs with niacinamide and an antioxidant system to help control color change.
Application
AC-α-Arbutin Application and Processing Guide
Protect Alpha-Arbutin from unnecessary heat and oxidation while controlling pH and finished-product use level.
- Dissolve in the water phase Use the 151 g/L cold-water solubility at 20°C as a starting point and mix until the solution is clear.
- Keep processing below 40°C Add during cool-down or use a low-temperature process where practical to reduce unnecessary thermal exposure.
- Maintain pH 5-7 Adjust and monitor the final formula pH throughout stability testing.
- Control oxidation and color Use a suitable antioxidant system and confirm compatibility with UV filters, ethanol, preservatives and packaging.
Recommended Formula Systems
Brightening serum
Essence
Face cream
Body lotion
BB / CC cream
Mask
Sun care formulas
Uneven skin tone formulas
Confirm current target-market concentration limits, impurity requirements and claim wording before commercial release.
Documents and Support
AC-α-Arbutin Technical Documents and Data Support
Request the current specification and supporting study package before finalizing claims or target-market compliance.
Product Positioning
Recommended Product Positioning
Enzyme-produced, high-purity Alpha-Arbutin with assay at least 99%, high cold-water solubility and hydroquinone controlled to not more than 10 ppm for cosmetic brightening applications.
Technical Files to Request
Ask for the documents needed for specification review, regulatory review, sample testing and bulk order qualification.
FAQ
AC-α-Arbutin FAQ
Answers to common buyer questions about hydroquinone control, use level, processing, applications and test data.
What is AC-α-Arbutin used for?
AC-α-Arbutin is used in brightening serums, creams, lotions, masks, sun care formulas and BB/CC creams.
What is the hydroquinone specification?
Hydroquinone is controlled to not more than 10 ppm.
What use level should formulators consider?
Recommended levels are up to 2.0% for face and neck products, up to 0.5% for body products, and 0.5-2.0% for BB/CC creams. Confirm the final level against current target-market requirements.
How should AC-α-Arbutin be processed?
Dissolve it in the water phase, preferably below 40°C, and maintain the finished formula at pH 5-7 while controlling oxidation and color.
How does AC-α-Arbutin support brighter-looking skin?
AC-α-Arbutin inhibits tyrosinase to help reduce excess melanin formation. The one-month finished-emulsion test used 1% Alpha-Arbutin, so finished-product claims should follow the tested formula and conditions.
