BioSyn-Bisabolol is a natural ingredient with a purity of at least 95% (-)-alpha-bisabolol, offering a more effective way to calm skin compared to synthetic alternatives that often contain less active components.

Research on 3D skin models shows that a low 0.1% concentration can lower IL-1α by 72% and PGE2 by 62% after exposure to UVB rays, effectively reducing the physical signs of irritation and heat.

It also helps stop the swelling process by inhibiting 80% of nitric oxide and 77% of TNF-α in cell tests, ensuring that the skin stays calm under stress.

By removing impurities like Bisabolol Oxide B, this high-quality ingredient promotes faster healing and maintains a healthy skin barrier without the risk of unwanted reactions.

Anti-Inflammatory

When you face inflammatory reactions such as skin redness, heat, or stinging, BioSyn-Bisabolol can alleviate these discomforts through precise molecular intervention.

As a natural (-)-α configuration with a purity of ≥95%, it can reduce IL-1α release by 72% and nitric oxide (NO) production by 80% in 3D epidermal tests at a low use concentration of 0.1%.

Unlike synthetic products containing impurities and lower activity, this high-purity ingredient can directly block pro-inflammatory signals such as NF-kB, demonstrating soothing capabilities comparable to pharmacological control groups when dealing with UV damage and sensitive irritation.

Signal Interception at the Molecular Level

The main role of BioSyn-Bisabolol lies in its ability to enter skin tissue and prevent the transmission of inflammatory information by adjusting the way molecules move.

• Blocking Reaction Channels: It      can inhibit the opening of NF-kB and AP-1      signaling pathways. These two pathways are typically the starting points      for redness, swelling, heat, and pain after the skin is exposed to      external stimuli (such as pollution, UV rays).

• Inhibiting Protein Output: It      can reduce the production of iNOS (inducible Nitric Oxide      Synthase) and COX-2 (Cyclooxygenase-2). This means the      "production line" of pro-inflammatory substances inside the skin      is effectively slowed down.

• Multi-target Coverage: It does      not only target a single inflammatory pathway but can also simultaneously      reduce the activity of multiple pro-inflammatory substances such as IL-1β,      IL-6, and TNF-α.

In Vitro Cell Test Data

In a study on mouse macrophages (LPS-induced model), BioSyn-Bisabolol showed outstanding inhibition of inflammatory indicators, with specific data shown in the table below:

These data indicate that natural configuration bisabolol is far more efficient in handling cellular inflammatory responses than chemically synthesized racemates.

3D Epidermal Model Simulation Study

To more realistically simulate the reaction of human skin under ultraviolet (UVB) irradiation, technicians conducted tests on the EpiKutis® 3D epidermal model.

At a concentration of only 0.1%, BioSyn-Bisabolol demonstrated extremely strong protective capabilities:

1. IL-1α Inhibition: Reduced by 72%.      This is one of the earliest warning signals after skin damage.

2. PGE2 Blockage: Reduced by 62%.      PGE2 is the main mediator leading to skin pain and swelling.

3. IL-6 Control: The inhibition      rate is 59%. In this indicator, its performance even      exceeds commonly used pharmacological reference substances      (dexamethasone).

Differences in Purity and Safety

Many bisabolols on the market are chemically synthesized, while BioSyn-Bisabolol ensures component uniqueness through biotechnology.

By eliminating Bisabolol Oxide B generated during the synthesis process, it not only improves safety but also avoids the additional burden of impurities on the skin barrier, allowing the ingredient to focus more on its repair function.

Anti-Irritant

In skin care formulations, bisabolol, as a monocyclic sesquiterpene alcohol, exhibits significant biological activity at concentrations between 0.1% and 0.5%.

Clinical data show that it can target and inhibit the production of PGE2 (Prostaglandin E2) and LTB4 (Leukotriene B4), thereby reducing erythema reactions caused by ultraviolet rays or chemical substances.

Experiments show that treating skin irritated by SLS (Sodium Lauryl Sulfate) with a 0.5% concentration of bisabolol can reduce the visual erythema score by more than 25% within 24 hours.

Due to its molecular weight of only 222.37 g/mol and its lipophilic nature, it can rapidly penetrate into the dermis to exert its effects.

How to Reduce Skin Discomfort

The main source of bisabolol is the extract of the Candeia tree from Brazil and Chamomile, and its active form is levomenol.

Differences Between Natural and Synthetic

There are two types of bisabolol on the market: natural extract and artificial synthesis, which have significant differences in anti-irritation efficiency.

• Natural Source (L-alpha configuration): Purity is usually above 95%. Because it is a      single active isomer, its biological activity is higher than      that of synthetic products.

• Synthetic Source (DL-alpha configuration): Contains four isomers, of which have lower actual biological      activity; therefore, higher addition concentrations are often required to      achieve the same effect.

Buffering Effect in Potent Products

Bisabolol is often used in formulations containing Retinol or AHA/BHA (Alpha Hydroxy Acid/Beta Hydroxy Acid) to balance the side effects these highly active ingredients may bring:

1. Acid Formulations: Adding 0.1%      bisabolol to 10% concentration AHA products can reduce      the burning sensation of the skin during initial use.

2. Retinol Products: It helps      alleviate desquamation and dryness caused by accelerated cell turnover;      experiments have observed that when used in combination, the skin's      tolerance period can be shortened by approximately 1/3.

3. Synergistic Combination: When      bisabolol is compounded with Ginger Root Extract in a 1:1      ratio, due to the presence of [6]-gingerol, its effect in      reducing redness is doubled compared to using it alone.

Application Recommendations and Safety

Bisabolol is a GRAS (Generally Recognized As Safe) substance and is widely recognized in international skin care standards.

• Stability: It performs stably      within a range of pH 4.0 to9.0, suitable for most lotions      and serums.

• Odor and Appearance: It is a      transparent, slightly viscous liquid with a very faint woody scent, and      will not affect the product's color or main odor.

• Non-allergenic: Even at a high      concentration of 1.0% in human patch tests, allergic      records are rarely generated, making it suitable for long-term use on      sensitive skin types.

Healing Properties

BioSyn-Bisabolol relies on the monomer (-)-α-configuration with a purity of over 95% to activate skin repair.

At a concentration of 3μg/ml, its inhibition rates for NO and TNF-α reach 80% and 77% respectively.

Through EpiKutis® 3D epidermal model testing, an addition of 0.1% can reduce the release of IL-1α by 72% and PGE2 by 62%.

In inhibiting the IL-6 inflammatory marker (inhibition rate of 59%), its performance exceeds the common control substance dexamethasone, providing quantified molecular-level protection for damaged tissues.

Molecular Inhibition of Inflammatory Pathways

After skin is subjected to ultraviolet rays or physical damage, it releases a large amount of inflammatory mediators.

BioSyn-Bisabolol acts directly on the NF-kB and AP-1 signaling pathways to reduce the production of pro-inflammatory proteins at the source.

Reactive Oxygen Species (ROS) Scavenging and Tissue Protection

Oxidative stress during the healing process can damage cellular DNA.

BioSyn-Bisabolol shows a significant concentration-dependent antioxidant capacity.

• Respiratory Burst Interference: Observed through Luminol-Amplified Chemiluminescence (LACL)      technology, it can effectively inhibit ROS produced by neutrophils.

• Effective Concentration Range:      Within the range of 3.8 to 31g/ml, it has a significant blocking effect on      the oxidative reaction induced by fMLP stimulation.

• Lipid Protection: Reduces the      damage of oxidative reactions to cell membrane lipids, maintaining the      stability of the healing environment.

Multidimensional Functions Assisting Healing

In addition to direct anti-inflammation, this ingredient also accelerates skin recovery by improving the environment.

1. Microbial Environment Management
        It has an inhibitory effect on Staphylococcus aureus and Candida albicans.      On the surface of wounds or damaged skin, this antibacterial property      reduces the risk of secondary infection.

2. Transdermal Flux Enhancement
        Experimental data show that it can improve the permeability of different      lipophilic components. While maintaining skin moisture (reducing TEWL), it      helps other repair ingredients enter deeper layers of the skin.

3. Post-healing Pigment Management
        By inhibiting the production of cAMP, it blocks melanin synthesis signals.      This helps reduce skin discoloration that may occur after inflammation,      making the skin tone more even after healing.