Blog
December. 31 2025
Discover AC-GLA, a high-purity glycolic acid designed for modern skincare formulations. Learn about its efficacy, mechanism, applications, and advantages for global cosmetic brands.
Introduction to AC-GLA Glycolic Acid
In today’s efficacy-driven skincare market, brands and formulators are looking for active ingredients that are clinically proven, formulation-friendly, and globally compliant. AC-GLA meets all these expectations. As a premium glycolic acid (INCI: Glycolic Acid), AC-GLA is engineered to deliver consistent performance in skin renewal, acne care, brightening, and anti-aging products.
Glycolic acid is the smallest molecular weight alpha hydroxy acid (AHA), allowing it to penetrate the skin efficiently and act quickly. AC-GLA takes this proven molecule a step further by offering high purity, excellent stability, and versatile formats, making it ideal for both mass and professional skincare applications.
What Is AC-GLA?
AC-GLA is a cosmetic-grade glycolic acid available in two specifications:
AC-GLA 99% – a highly purified crystalline form, ideal for anhydrous or low-water formulations
AC-GLA 70% – a ready-to-use aqueous solution, nearly colorless and low-odor, designed for easy formulation
Thanks to advanced manufacturing and strict quality control, AC-GLA delivers transparent quality, stable performance, and controlled impurity levels, meeting the expectations of international cosmetic brands.
Why Glycolic Acid Is the Gold Standard of AHAs
Among all AHAs, glycolic acid stands out due to its:
Small molecular size (76.05 Da) for strong skin penetration
High bioavailability at controlled pH levels
Proven dermatological history in both cosmetic and clinical use
These properties make glycolic acid especially effective for improving skin texture, tone, and clarity. AC-GLA leverages these intrinsic advantages while ensuring safety and consistency for commercial formulations.

How AC-GLA Works: Scientifically Proven Mechanisms
AC-GLA supports skin renewal through multiple, well-studied biological pathways:
1. Anti-Acne Activity
AC-GLA inhibits the growth of Cutibacterium acnes, helping reduce acne lesions and prevent pore congestion. This makes it a valuable active in acne-prone and oily skin formulations.
2. Anti-Inflammatory Action
By suppressing the UVB-activated NF-κB signaling pathway, AC-GLA helps reduce the release of inflammatory mediators such as IL-1β, IL-6, and TNF-α. This contributes to calmer, healthier-looking skin.
3. Skin Renewal & Exfoliation
AC-GLA activates enzymes that reduce adhesion between corneocytes, promoting controlled exfoliation. As old keratinocytes shed, skin appears smoother, brighter, and more even-toned.
4. Anti-Aging & Skin Repair
Studies show glycolic acid can:
Increase Type I collagen mRNA expression
Enhance hyaluronic acid content in both epidermis and dermis
These effects help improve elasticity, reduce fine lines, and support long-term skin rejuvenation.
Key Benefits of AC-GLA in Skincare Products
When incorporated correctly, AC-GLA delivers multiple visible benefits:
Gently exfoliates to reveal fresher, radiant skin
Improves skin tone and reduces dullness
Fades dark spots and hyperpigmentation
Helps smooth fine lines and wrinkles
Enhances hydration and boosts absorption of other actives
These benefits make AC-GLA suitable for daily care products as well as high-performance treatment formulas.
Formulation Advantages of AC-GLA
AC-GLA is designed with formulators in mind:
Excellent water solubility
Low odor and high clarity
Stable quality over long-term storage
Good compatibility with other cosmetic actives
Available for both aqueous and anhydrous systems
For brands seeking flexibility, AC-GLA offers reliable performance across a wide range of product concepts.
Recommended Usage Levels
Typical dosage ranges depend on product type and target effect:
Product Type | Recommended Level | Typical pH |
Daily skincare | < 3% | ≥ 3.5 |
Functional / acne care | 3–6% | 3.0–3.5 |
Professional use | > 6% | < 3.5 |
Maintaining an appropriate pH is essential to balance efficacy and skin tolerance.
Applications Across Beauty & Personal Care
AC-GLA is widely used in:
Facial cleansers
Toners and essences
Serums and ampoules
Creams and lotions
Masks and peeling products
Hair and scalp care
Nail and cuticle treatments
Its versatility allows brands to create cohesive product lines centered around exfoliation, renewal, and skin clarity.

Global Regulatory Compliance
AC-GLA is compliant with major cosmetic regulations:
China: IECIC (2021 Edition)
United States: PCPC
European Union: CosIng / EC No. 1223/2009
This global acceptance makes AC-GLA a reliable choice for international product launches.
FAQs About AC-GLA
1. Is AC-GLA suitable for sensitive skin products?
Yes, when used at appropriate concentrations and pH levels, AC-GLA can be formulated for gentle, controlled exfoliation.
2. What makes AC-GLA different from standard glycolic acid?
AC-GLA offers higher purity, better stability, and formulation flexibility, especially with its 99% anhydrous option.
3. Can AC-GLA be combined with other actives?
Yes. AC-GLA shows good compatibility and can even enhance the performance of other functional ingredients.
4. Is AC-GLA only for facial skincare?
No. It is also suitable for body care, hair care, and nail care applications.
5. Does AC-GLA help with anti-aging?
Yes. Its ability to stimulate collagen and hyaluronic acid supports visible anti-aging benefits.
6. Is AC-GLA biodegradable?
Yes, glycolic acid is biodegradable and aligns with modern sustainability expectations.
Conclusion: Why Choose AC-GLA
For cosmetic brands and formulators seeking a reliable, science-backed AHA, AC-GLA stands out as a premium glycolic acid solution. Its proven efficacy, formulation versatility, and global regulatory compliance make it an excellent choice for next-generation skincare and personal care products.
To learn more about glycolic acid and formulation best practices, you can also explore educational resources.